1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

Base Information

Chemical Name:1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one
CAS No.:99780-99-1
Molecular Formula:C₂₅H₃₈N₂O₅
Molecular Weight:446.587
Hs Code.:

Synonyms:1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

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Technology Process of 1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

There total 13 articles about 1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 81867-06-3
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-aminoperhydroazocin-2-one

: 81867-25-6,81867-32-5,81897-51-0,99780-99-1,99781-00-7,99781-01-8,99781-02-9
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

: 81867-25-6,81867-32-5,81897-51-0,99780-99-1,99781-00-7,99781-01-8,99781-02-9
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; under 2068.6 Torr; Ambient temperature;
DOI:10.1021/jm00152a014

Reference yield: 35.0%

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 81867-06-3
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-aminoperhydroazocin-2-one

: 81867-25-6,81867-32-5,81897-51-0,99780-99-1,99781-00-7,99781-01-8,99781-02-9
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

: 81867-25-6,81867-32-5,81897-51-0,99780-99-1,99781-00-7,99781-01-8,99781-02-9
(+/-)-1-<(tert-butoxycarbonyl)methyl>-3-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; under 2068.6 Torr; Ambient temperature;
DOI:10.1021/jm00152a014

Reference yield:

: 32566-61-3
3-bromohexahydroazocin-2(1H)-one

: 99780-99-1
1-<(tert-butoxycarbonyl)methyl>-3(R)-<<1(R)-(ethoxycarbonyl)-3-phenylpropyl>amino>perhydroazocin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / sodium azide / ethanol; H₂O

2: 76 percent / NaH / tetrahydrofuran / 1.5 h / Heating

3: 100 percent / H₂ / 10percent Pd/C

5: sodium acetate, sodium borohydride / ethanol

With sodium tetrahydroborate; sodium azide; hydrogen; sodium acetate; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00152a014