3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

Base Information

Chemical Name:3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine
CAS No.:1428934-98-8
Molecular Formula:C₂₄H₂₅N₅O₃S
Molecular Weight:465.544
Hs Code.:

Synonyms:3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

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Chemical Property of 3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

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Technology Process of 3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

There total 12 articles about 3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1428935-37-8
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-(4-isopropylsulfonylphenyl)pyrazin-2-yl]isoxazol-3-yl]phenyl]dideuteriomethyl]-N-methylcarbamate

: 1428934-98-8
3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; for 16h; Reflux;

Reference yield:

: 1428935-59-4
C₉H₁₂BrN₃Si*C₇H₈O₃S

: 1428934-98-8
3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydrogencarbonate / water; ethyl acetate / 0.5 h

1.2: 0.5 h

1.3: charcoal (Darco G-60); Celite / 2 h

2.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran / 3 h / 65 °C

4.1: hydrogenchloride / methanol; dichloromethane / 16 h / Reflux

With hydrogenchloride; potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1428934-98-8
3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / dichloromethane / 2 h / 20 °C

2: bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium phosphate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 3 h / 65 °C

4: hydrogenchloride / methanol; dichloromethane / 16 h / Reflux

With hydrogenchloride; dmap; potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;