Technology Process of (3-hydroxy-4-methoxybenzoyl)-1-piperazine
There total 3 articles about (3-hydroxy-4-methoxybenzoyl)-1-piperazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 4-(3-hydroxy-4-methoxybenzoyl)-1-piperazinecarboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
water;
DOI:10.1002/cmdc.201100207
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C / Iennert atmosphere
2: triethylamine / dichloromethane / 2.17 h / 0 - 20 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
With
thionyl chloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1002/cmdc.201100207
- Guidance literature:
-
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 2.17 h / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
With
triethylamine; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1002/cmdc.201100207
