benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone

Base Information

• Chemical Name: benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone
• CAS No.: 1394973-41-1
• Molecular Formula: C₁₆H₁₃NOS
• Molecular Weight: 267.351
• Mol file: 1394973-41-1.mol

Synonyms:benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone

Chemical Property of benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone

There total 6 articles about benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1,3-Benzothiazole (95-16-9) + N-methoxy-N,2,4-trimethylbenzamide → benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone (1394973-41-1)

Guidance literature:

1,3-Benzothiazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

N-methoxy-N,2,4-trimethylbenzamide; In tetrahydrofuran; at -78 - 20 ℃; for 24h;

DOI:10.1002/cmdc.202100368

Reference yield: 67.0%

2-Chloronitrobenzene (88-73-3) + 2,4-dimethylacetophenone. (89-74-7) → benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone (1394973-41-1)

Guidance literature:

With 4-methyl-morpholine; sulfur; at 140 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01182

Reference yield:

2,4-dimethylstyrene (2234-20-0) → benzo[d]thiazol-2-yl(2,4-dimethylphenyl)methanone (1394973-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; iodine / dimethyl sulfoxide / 80 °C / Sealed tube

2: dimethyl sulfoxide / 80 °C / Sealed tube

With iodine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide;

DOI:10.1021/ol301921t

upstream raw materials:

2,4-dimethylstyrene

2-amino-benzenethiol

2-Chloronitrobenzene

2,4-dimethylacetophenone.