N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Base Information

Chemical Name:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide
CAS No.:919530-72-6
Molecular Formula:C₄₂H₄₄N₆O₇
Molecular Weight:744.847
Hs Code.:

<i>N</i>-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-<i>p</i>-tolylamino-6,9-dihydro-1<i>H</i>-purin-2-yl)-isobutyramide

Synonyms:N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Chemical Property of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

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Technology Process of N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

There total 14 articles about N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 919530-65-7
N²-isobutyryl-8N-(4-methylphenylamino)-2'-deoxyguanosine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 919530-72-6
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: In pyridine; at 20 ℃; for 3h;
DOI:10.1021/jo061803t

Reference yield: 72.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 919530-65-7
N-[6-hydroxy-9-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-8-p-tolylamino-9H-purin-2-yl]-isobutyramide

: 919530-72-6
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-hydroxy-8-p-tolylamino-9H-purin-2-yl)-isobutyramide

Guidance literature:: With pyridine; dmap; at 20 ℃; for 12h;
DOI:10.1055/s-2002-25354

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 919530-72-6
N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-oxo-8-p-tolylamino-6,9-dihydro-1H-purin-2-yl)-isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / K₃PO₄; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / 1,2-dimethoxy-ethane / 50 h / 80 °C

2: 99 percent / hydrogen / Pd/C / methanol / 1 h / 20 °C

3: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4: 72 percent / pyridine / 3 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane;
DOI:10.1021/jo061803t