9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine

Base Information

• Chemical Name: 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine
• CAS No.: 385806-26-8
• Molecular Formula: C₁₄H₁₅BrN₄O₅
• Molecular Weight: 399.201
• Mol file: 385806-26-8.mol

Synonyms:9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine

Chemical Property of 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine

There total 1 articles about 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3',5'-di-O-acetyl-2'-deoxyadenosine (17318-24-0) → 9-(3',5'-di-O-acetyl-2'-deoxy-β-D-erythro-pentofuranosyl)-1H-purine-6(9H)-one (106568-79-0) + 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine (385806-26-8)

Guidance literature:

With tert.-butylnitrite; trimethylsilyl bromide; 1,1-dibromomethane; at 0 - 5 ℃;

DOI:10.1021/jo020625a

Reference yield: 91.0%

p-toluidine (106-49-0,12221-03-3) + 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine (385806-26-8) → 3',5'-di-O-acetyl-N6-(p-tolyl)-2'-deoxyadenosine

Guidance literature:

In methanol; at 65 ℃; for 12h;

DOI:10.1021/jo016078v

Reference yield: 85.0%

aniline (62-53-3) + 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine (385806-26-8) → C20H21N5O5 (1379667-62-5)

Guidance literature:

With 6,6'-bis(diphenylphosphanyl)-2,2',3,3'-tetrahydro-5,5'-bi-1,4-benzodioxin; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201103918

upstream raw materials:

3',5'-di-O-acetyl-2'-deoxyadenosine

Downstream raw materials:

3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine

C₂₀H₂₁N₅O₅