Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

Base Information

Chemical Name:Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate
CAS No.:106585-59-5
Molecular Formula:C₃₂H₄₀N₄O₈
Molecular Weight:608.692
Hs Code.:

Synonyms:Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

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Chemical Property of Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

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Technology Process of Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

There total 6 articles about Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.3%

: 2378-95-2
diethyl N-<4-(methylamino)benzoyl>-L-glutamate

: 106585-53-9
<6-(bromomethyl)-4-oxo-3(4H)-quinazolinyl>methyl 2,2-dimethylpropanoate

: 106585-59-5
Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

Guidance literature:: With calcium carbonate; In dimethyl amine; at 50 ℃; for 24h;
DOI:10.1021/jm00124a018

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 106585-59-5
Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 77.3 percent / 1) 130 deg C, 1h, 2.) 180 deg C, 1 h

2: 1.) NaH / 1.) DMF, 30 min., 2.) 25 deg C, 2 h

3: 76.3 percent / N-bromosuccinimide / CCl₄ / 0.33 h / Heating; Irradiation

4: 89.3 percent / CaCO₃ / dimethylamine / 24 h / 50 °C

With N-Bromosuccinimide; sodium hydride; calcium carbonate; In tetrachloromethane; dimethyl amine;
DOI:10.1021/jm00124a018

Reference yield:

: 19181-53-4
6-methyl-3H-quinazolin-4-one

: 106585-59-5
Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 30 min., 2.) 25 deg C, 2 h

2: 76.3 percent / N-bromosuccinimide / CCl₄ / 0.33 h / Heating; Irradiation

3: 89.3 percent / CaCO₃ / dimethylamine / 24 h / 50 °C

With N-Bromosuccinimide; sodium hydride; calcium carbonate; In tetrachloromethane; dimethyl amine;
DOI:10.1021/jm00124a018