4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

Base Information

Chemical Name:4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid
CAS No.:1290049-65-8
Molecular Formula:C₁₅H₁₈Cl₂N₂O₃
Molecular Weight:345.226
Hs Code.:

Synonyms:4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

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Chemical Property of 4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

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Technology Process of 4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

There total 4 articles about 4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290049-64-7
4-[[(R)-2-(3,4-dichloro-phenylamino)-propionyl]-(2,2-dimethoxy-ethyl)-amino]-butyric acid tert-butyl ester

: 1290049-65-8
4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

: 4-[(S)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

Guidance literature:: 4-[[(R)-2-(3,4-dichloro-phenylamino)-propionyl]-(2,2-dimethoxy-ethyl)-amino]-butyric acid tert-butyl ester; With triethylamine; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1.5h;

With triethylsilane; In dichloromethane; at 0 ℃; for 16h;

Reference yield:

: 4-[[2-(3,4-dichloro-phenylamino)-propionyl]-(2,2-dimethoxy-ethyl)-amino]-butyric acid tert-butyl ester

: 1290049-65-8
4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

: 4-[(S)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

Guidance literature:: 4-[[2-(3,4-dichloro-phenylamino)-propionyl]-(2,2-dimethoxy-ethyl)-amino]-butyric acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

With triethylsilane; In dichloromethane; for 16h;

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 20555-91-3
3,4-dichloroiodobenzene

: 1290049-65-8
4-[(R)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

: 4-[(S)-4-(3,4-dichloro-phenyl)-3-methyl-2-oxo-piperazin-1-yl]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; 2-hydroxybenzaldehyde phenylhydrazone / copper(l) iodide / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 0 °C

3.1: triethylamine; trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C

3.2: 16 h / 0 °C

With potassium phosphate; triethylamine; HATU; trifluoroacetic acid; 2-hydroxybenzaldehyde phenylhydrazone; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;