N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

Base Information

Chemical Name:N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide
CAS No.:188913-71-5
Molecular Formula:C₂₉H₃₅N₅O₅S
Molecular Weight:565.693
Hs Code.:

Synonyms:N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

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Chemical Property of N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

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Technology Process of N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

There total 1 articles about N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 39628-94-9
4-nitrobenzyl methanesulfonate

: N-(1-ethoxymethyl-3-methyl-butyl)-4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzenesulfonamide

: 188913-71-5
N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

Guidance literature:: N-(1-ethoxymethyl-3-methyl-butyl)-4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzenesulfonamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-nitrobenzyl methanesulfonate; In tetrahydrofuran; at 20 ℃; for 18h; Further stages.;
DOI:10.1021/jm010852p

Reference yield: 46.0%

: 188913-71-5
N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

: 188913-72-6
N-(4-amino-benzyl)-N-(1-ethoxymethyl-3-methyl-butyl)-4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzenesulfonamide

Guidance literature:: With hydrogen; 10percent Pd/C; In methanol; for 18h; under 760.051 Torr;
DOI:10.1021/jm010852p

Reference yield:

: 188913-71-5
N-(4-nitrobenzyl)-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

: N-[4-(4-hydroxy-3-carboxyphenylazo)benzyl]-N-[(S)-1-isobutyl-2-ethoxyethyl]-4-(1H-2-methylimidazo[4,5-c]pyridylmethyl)phenylsulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 46 percent / H₂ / 10percent Pd/C / methanol / 18 h / 760.05 Torr

2.1: aq. HCl; aq. NaNO₂ / 0 °C

2.2: 35 percent / aq. NaOH / 0.5 h / 18 °C

With hydrogenchloride; hydrogen; sodium nitrite; 10percent Pd/C; In methanol;
DOI:10.1021/jm010852p