(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

Base Information

Chemical Name:(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate
CAS No.:1360790-08-4
Molecular Formula:C₂₆H₂₈N₄O₄
Molecular Weight:460.533
Hs Code.:

Synonyms:(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

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Chemical Property of (((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

Chemical Property:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

There total 2 articles about (((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 714272-27-2
(3Z,6Z)-3-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6-(phenylmethylene)piperazine-2,5-dione

: 1360790-07-3
chloromethyl hex-5-ynoate

: 1360790-08-4
(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 0.25h; Microwave irradiation;
DOI:10.1002/chem.201102293

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 1360790-08-4
(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate / dichloromethane; water / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 50 °C / Microwave irradiation

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; caesium carbonate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201102293

Reference yield: 91.0%

: 1360790-08-4
(((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methyl hex-5-ynoate

: 104768-72-1
(R)-4-Azido-3-hydroxybutanoic acid

: 1366139-24-3
(R)-4-(4-(4-((((3Z,6Z)-6-benzylidene-3-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)-5-oxo-3,4,5,6-tetrahydropyrazin-2-yl)oxy)methoxy)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)-3-hydroxybutanoic acid

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol; at 80 ℃; for 0.166667h; Microwave irradiation;