(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate
CAS No.:1122573-49-2
Molecular Formula:C₁₆H₁₉NO₃
Molecular Weight:273.332
Hs Code.:

Synonyms:(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

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Chemical Property of (1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

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Technology Process of (1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

There total 1 articles about (1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 135747-07-8
methyl 2-diazo-3-oxo-3-(pyrrolidin-1-yl)propanoate

: 1122573-49-2
(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

Guidance literature:: With C₃₆H₃₂N₂O₈Rh; In 1,2-dichloro-ethane; at 20 ℃; for 26h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.200804586

Reference yield: 89.0%

: 1122573-49-2
(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

: 1122573-78-7
(2-phenyl-1-(pyrrolidin-1-ylmethyl)cyclopropyl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; optical yield given as %ee;
DOI:10.1002/anie.200804586

Reference yield: 77.0%

: 109-72-8,29786-93-4
n-butyllithium

: 1122573-49-2
(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate

: 1198574-01-4
((1S,2R)-1-(5-hydroxynonan-5-yl)-2-phenylcyclopropyl)(pyrrolidin-1-yl)methanone

Guidance literature:: n-butyllithium; With copper(l) cyanide; In diethyl ether; hexane; at -78 - 25 ℃; Inert atmosphere;

(1R,2R)-methyl 2-phenyl-1-(pyrrolidin-1-ylcarbonyl)cyclopropanecarboxylate; In diethyl ether; hexane; dichloromethane; at -78 - 25 ℃; Inert atmosphere;

With water; ammonium chloride; In diethyl ether; hexane; dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jo902066y