(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

Base Information

Chemical Name:(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate
CAS No.:750649-48-0
Molecular Formula:C₂₂H₂₃ClN₂O₅
Molecular Weight:430.888
Hs Code.:

Synonyms:(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

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Chemical Property of (3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

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Technology Process of (3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

There total 4 articles about (3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 159112-23-9
3-(4-chlorophenyl)-4-nitrobutanoic acid

: 169221-12-9
(S)-3-hydroxy-4,4-dimethyl-1-phenyl-2-pyrrolidinone

: 750649-48-0
(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

: (3R,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2004.05.021

Reference yield:

: 20754-21-6
methyl 3-(4-chlorophenyl)propenoate

: 750649-48-0
(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / K₂CO₃; BnEt₃NCl / toluene / 24 h / 20 °C

2: 85 percent / AcOH; aq. HCl / 1 h / Heating

3: 21 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1016/j.tetasy.2004.05.021

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 750649-48-0
(3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / SOCl₂

2: 72 percent / K₂CO₃; BnEt₃NCl / toluene / 24 h / 20 °C

3: 85 percent / AcOH; aq. HCl / 1 h / Heating

4: 21 percent / DCC; DMAP / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1016/j.tetasy.2004.05.021