(R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol

Base Information

• Chemical Name: (R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol
• CAS No.: 958292-71-2
• Molecular Formula: C₂₁H₂₉NO₄
• Molecular Weight: 359.466
• Mol file: 958292-71-2.mol

Synonyms:(R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol

Chemical Property of (R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol

There total 1 articles about (R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanone hydrochloride → (R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol (958292-71-2) + (S)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol

Guidance literature:

With hydrogen; [Rh(Et-(1,2-bis(2,5-dimethylphospholano)benzene))(cod)]*BF₄; In methanol; at 50 ℃; for 12h; under 38002.6 Torr; Title compound not separated from byproducts.;

DOI:10.1002/chem.200700594

Reference yield: 85.0%

(R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol (958292-71-2) → Arbutamine (130783-37-8)

Guidance literature:

With boron tribromide;

DOI:10.1002/chem.200700594

Reference yield:

(R)-1-(3,4-dimethoxy-phenyl)-2-[4-(4-methoxy-phenyl)-butylamino]-ethanol (958292-71-2) + acetic anhydride (108-24-7) → N-[2-(3,4-dimethoxy-phenyl)-2-hydroxy-ethyl]-N-[4-(4-methoxy-phenyl)-butyl]-acetamide

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1002/chem.200700594

Downstream raw materials:

Arbutamine