(R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene

Base Information

• Chemical Name: (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene
• CAS No.: 1016652-35-9
• Molecular Formula: C₂₅H₃₆OSi
• Molecular Weight: 380.646
• Mol file: 1016652-35-9.mol

Synonyms:(R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene

Chemical Property of (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene

There total 1 articles about (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-tolylmagnesium bromide (932-31-0) + (S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate (1016652-32-6) → (R,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene (1016652-35-9) + (S,E)-1-[(tert-butyldimethylsilyl)oxy]-2-(2-methylphenyl)-6-phenyl-3-hexene

Guidance literature:

ortho-tolylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; Cooling with ice;

(S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate; In tetrahydrofuran; at -60 - -40 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol800300x

upstream raw materials:

ortho-tolylmagnesium bromide

(S,Z)-6-[(tert-butyldimethylsilyl)oxy]-1-phenylhex-4-en-3-yl pyridine-2-carboxylate