(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

Base Information

Chemical Name:(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid
CAS No.:213390-87-5
Molecular Formula:C₅₂H₈₈O₁₀Si
Molecular Weight:901.35
Hs Code.:

(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

Synonyms:(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

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Chemical Property of (2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

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Technology Process of (2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

There total 9 articles about (2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 213390-86-4
C₆₀H₁₀₄O₁₀Si₂

: 213390-87-5
(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; at 20 ℃;
DOI:10.1016/S0040-4039(98)01192-7

Reference yield:

: 210709-28-7
C₆₀H₁₀₄O₉Si₂

: 213390-87-5
(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / sodium chlorite, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 18 h / 20 °C

2: 90 percent / HF*pyr / pyridine; tetrahydrofuran / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)01192-7

Reference yield:

: 210709-24-3
C₆₆H₁₂₀O₉Si₃

: 213390-87-5
(2E,4E)-6-[(2S,4R,5R,6R)-6-((5E,11E)-(1R,4S,8R,10R,14S,15R,16S,17S)-14,16-Dihydroxy-4,10-dimethoxy-1,5,8,15,17-pentamethyl-18-triisopropylsilanyloxy-octadeca-5,11-dienyl)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-hexa-2,4-dienoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / DDQ, pH₇ buffer / CH₂Cl₂ / 0.17 h / 0 °C

2: 91 percent / sodium chlorite, NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 18 h / 20 °C

3: 90 percent / HF*pyr / pyridine; tetrahydrofuran / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; pH₇ buffer; pyridine hydrogenfluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; pyridine; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)01192-7