4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol

Base Information

• Chemical Name: 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol
• CAS No.: 871711-78-3
• Molecular Formula: C₂₁H₂₆O₇
• Molecular Weight: 390.433
• Mol file: 871711-78-3.mol

Synonyms:4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol

Chemical Property of 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol

There total 4 articles about 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(7R,8S)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-(6''-O-syringoyl)-β-D-glucopyranoside → β-D-glucose (492-61-5) + 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol (871711-78-3) + 3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) + 5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (545436-58-6)

Guidance literature:

With water; cellulase; In chloroform; at 40 ℃; for 112h; Enzymatic reaction;

DOI:10.1016/j.phytol.2012.01.003

Reference yield:

(7R,8S)-3,5,3′-trimethoxy-4′,7-epoxy-8,5′-neolignan-4,9,9′-triol 9-O-α-L-rhamnopyranoside → 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol (871711-78-3)

Guidance literature:

With naringinase from Penicillum; In water; at 40 ℃; for 24h; Enzymatic reaction;

DOI:10.1021/acs.jnatprod.5b00090

Reference yield:

4-hydroxy-3,5,5′-trimethoxy-4′,7-epoxy-8,3′-neoligna-9,9′-ol → (7S,8R)-4-hydroxy-3,5,5′-trimethoxy-4′,7-epoxy-8,3′-neoligna-9,9′-ol + 4-[(2R,3S)-2,3-dihydro-3-(hydroxymethyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-2-yl]-2,6-dimethoxyphenol (871711-78-3)

Guidance literature:

With Daicel Chiralpak AD-H column; In hexane; isopropyl alcohol; Resolution of racemate;

DOI:10.1016/j.bioorg.2020.104147