(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate
CAS No.:1400991-76-5
Molecular Formula:C₂₉H₂₆F₆N₄O₄
Molecular Weight:608.54
Hs Code.:

Synonyms:(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

There total 4 articles about (S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₁N₅O₄

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1400991-76-5
(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; In toluene; at 20 ℃; for 50h; Sonication;
DOI:10.1016/j.tet.2012.08.023

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1400991-76-5
(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C

2.2: pH 2

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 - -10 °C

3.2: 0.08 h / -5 °C

4.1: 4-methyl-morpholine / toluene / 50 h / 20 °C / Sonication

With 4-methyl-morpholine; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2012.08.023

Reference yield:

: 19883-41-1,13226-98-7
D-phenylglycine methyl ester hydrochloride

: 1400991-76-5
(S)-benzyl 2-{(S)-1-[3-(3,5-bis(trifluoromethyl)phenyl)ureido](phenyl)methylcarbamoyl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C

2.2: pH 2

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 - -10 °C

3.2: 0.08 h / -5 °C

4.1: 4-methyl-morpholine / toluene / 50 h / 20 °C / Sonication

With 4-methyl-morpholine; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1016/j.tet.2012.08.023