3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

Base Information

Chemical Name:3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine
CAS No.:105189-37-5
Molecular Formula:C₂₁H₁₈Br₂N₂O₅
Molecular Weight:538.192
Hs Code.:

Synonyms:3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

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Technology Process of 3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

There total 9 articles about 3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 105189-37-5
3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

Guidance literature:

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 105189-37-5
3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N / CH₂Cl₂ / 19 h / Ambient temperature

6: BBr₃ / CH₂Cl₂ / 2 h / -55 deg C to room temperature

7: conc. HCl / acetic acid / 16.5 h / Heating

With pyridine; hydrogenchloride; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; boron tribromide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00122a009

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 105189-37-5
3,5-dibromo-3'-<(2-oxo-1,2-dihydropyrid-5-yl)methyl>-L-thyronine

Guidance literature:: Multi-step reaction with 7 steps

1: 1) n-BuLi / 1) THF, hexane, -85 deg C, 5 min, 2) THF, below -70 deg C to room temperature

2: pyridine / 50 °C

3: H₂ / 10percent Pd/C / methanol

4: 1) iodine tris(trifluoroacetate), 2) NaClO₄ / 1) CF₃COOH, (CF₃CO)2O, room temperature, overnight, 2) CH₂Cl₂, H₂O, NaAc

5: Cu bronze, Et₃N / CH₂Cl₂ / 19 h / Ambient temperature

6: BBr₃ / CH₂Cl₂ / 2 h / -55 deg C to room temperature

7: conc. HCl / acetic acid / 16.5 h / Heating

With pyridine; hydrogenchloride; n-butyllithium; copper bronze; iodine tris(trifluoroacetate); sodium perchlorate; hydrogen; boron tribromide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00122a009