2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester

Base Information

• Chemical Name: 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester
• CAS No.: 334698-40-7
• Molecular Formula: C₁₉H₂₀O₆
• Molecular Weight: 344.364
• Mol file: 334698-40-7.mol

Synonyms:2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester

Chemical Property of 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester

There total 3 articles about 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-tolyl iodide (624-31-7) + 1,1-diethyl 2-propargyl ethene-1,1,2-tricarboxylate (431911-71-6) → 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester (334698-40-7)

Guidance literature:

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃;

DOI:10.1039/b008103p

Reference yield:

propargyl (triphenylphosphoranylidene)acetate → 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester (334698-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / benzene / 5 h / 20 °C

2: 46 percent / CuI; Et₂NH / PdCl₂(P(Ph)3) / 20 °C

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In benzene; 2: Sonogashira coupling;

DOI:10.1039/b008103p

Reference yield:

Diethyl ketomalonate (609-09-6) → 2-ethoxycarbonyl-but-2-enedioic acid 1-ethyl ester 4-(3-p-tolyl-prop-2-ynyl) ester (334698-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / benzene / 5 h / 20 °C

2: 46 percent / CuI; Et₂NH / PdCl₂(P(Ph)3) / 20 °C

With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In benzene; 2: Sonogashira coupling;

DOI:10.1039/b008103p

upstream raw materials:

4-tolyl iodide

1,1-diethyl 2-propargyl ethene-1,1,2-tricarboxylate

Diethyl ketomalonate