5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole

Base Information

• Chemical Name: 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole
• CAS No.: 158667-52-8
• Molecular Formula: C₂₅H₂₃N₇O₂
• Molecular Weight: 453.503
• Mol file: 158667-52-8.mol

Synonyms:5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole

Chemical Property of 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole

There total 2 articles about 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-nitrobenzenecarboximidic acid ethyl ester monohydrochloride (57508-53-9) + 2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline (23491-49-8) → 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole (158667-52-8)

Guidance literature:

With acetic acid; Heating;

Reference yield:

3-nitrobenzonitrile (619-24-9) → 5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole (158667-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / HCl / ethanol

2: 68 percent / glacial AcOH / Heating

With hydrogenchloride; acetic acid; In ethanol;

Reference yield: 84.0%

5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole (158667-52-8) → 3-amino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene (158667-56-2)

Guidance literature:

5-(4-methylpiperazin-1-yl)-2'-(3-nitrophenyl)-2,5'-bi-1H-benzimidazole; With hydrogen; acetic acid; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

With ammonia;

upstream raw materials:

3-nitrobenzenecarboximidic acid ethyl ester monohydrochloride

2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline

3-nitrobenzonitrile

Downstream raw materials:

3-amino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene