(4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline

Base Information

• Chemical Name: (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline
• CAS No.: 1269603-80-6
• Molecular Formula: C₁₉H₂₃N₅O₂
• Molecular Weight: 353.424
• Mol file: 1269603-80-6.mol

Synonyms:(4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline

Chemical Property of (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline

There total 3 articles about (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-N4-benzyloxycarbonyl-1,2,4-triaminobutane dihydrochloride + C8H11N3S*HI (1269487-61-7) → (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline (1269603-80-6)

Guidance literature:

(2S)-N⁴-benzyloxycarbonyl-1,2,4-triaminobutane dihydrochloride; C₈H₁₁N₃S*HI; In pentan-1-ol; for 24h; Reflux;

With sodium hydroxide; In water; pH=12;

DOI:10.1016/j.bmc.2010.11.039

Reference yield:

N-(6-methylpyridine-2-ylcarbamothioyl)benzamide (96938-51-1) → (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline (1269603-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / 0.67 h / 90 °C

2.1: methanol / 3 h / Reflux

3.1: pentan-1-ol / 24 h / Reflux

3.2: pH 12

With water; sodium hydroxide; In methanol; pentan-1-ol;

DOI:10.1016/j.bmc.2010.11.039

Reference yield:

(6-methyl-pyridin-2-yl)-thiourea (49600-34-2) → (4S)-4-(N-benzyloxycarbonyl-2-aminoethyl)-2-[(6-methylpyridyl-2)amino]imidazoline (1269603-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 3 h / Reflux

2.1: pentan-1-ol / 24 h / Reflux

2.2: pH 12

In methanol; pentan-1-ol;

DOI:10.1016/j.bmc.2010.11.039

upstream raw materials:

C₈H₁₁N₃S*HI

(6-methyl-pyridin-2-yl)-thiourea

N-(6-methylpyridine-2-ylcarbamothioyl)benzamide