(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

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Chemical Name:(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile
CAS No.:1160358-08-6
Molecular Formula:C₂₆H₂₁FN₆O
Molecular Weight:452.491
Hs Code.:

Synonyms:(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

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Chemical Property of (S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

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Technology Process of (S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

There total 12 articles about (S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1160358-07-5
(S)-(7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridin-5-yl)methanol

: 1160358-08-6
(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Guidance literature:: With ammonia; iodine; In water; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ml2000438

Reference yield:

: 1128105-86-1
C₁₅H₁₃BrFNO₃

: 1160358-08-6
(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: water; sodium hydroxide / methanol / 16 h / 20 °C / Inert atmosphere

2.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / -10 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol; dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

4.2: 4 h / 20 °C / Inert atmosphere

5.1: TurboGrignard / tetrahydrofuran / 0.5 h / Inert atmosphere

5.2: 16 h / 20 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C / Inert atmosphere

7.1: hydrazine hydrate / ethanol / 2 h / 80 °C / Inert atmosphere

8.1: pyridine; trichlorophosphate / 2 h / 50 °C / Inert atmosphere

9.1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / 20 °C / Inert atmosphere

10.1: ammonia; iodine / water / 3 h / 60 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; TurboGrignard; trifluoro-[1,3,5]triazine; ammonium cerium (IV) nitrate; ammonia; water; iodine; sodium hydride; Dess-Martin periodane; hydrazine hydrate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile; 6.1: Dess-Martin oxidation;
DOI:10.1021/ml2000438

Reference yield:

: 1128105-87-2
C₁₄H₁₃BrFNO₂

: 1160358-08-6
(S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-7H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: hydrazine hydrate / ethanol / 2 h / 80 °C / Inert atmosphere

5.1: pyridine; trichlorophosphate / 2 h / 50 °C / Inert atmosphere

6.1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / 20 °C / Inert atmosphere

7.1: ammonia; iodine / water / 3 h / 60 °C / Inert atmosphere

With pyridine; TurboGrignard; ammonium cerium (IV) nitrate; ammonia; water; iodine; sodium hydride; Dess-Martin periodane; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 3.1: Dess-Martin oxidation;
DOI:10.1021/ml2000438