Didesmethylsibutramine, (+)-

Base Information

Chemical Name:Didesmethylsibutramine, (+)-
CAS No.:229639-56-9
Molecular Formula:C₁₅H₂₂ClN
Molecular Weight:251.799
Hs Code.:
UNII:B408000HRV
DSSTox Substance ID:DTXSID90177513
Nikkaji Number:J1.352.498J
Wikidata:Q7389750

Synonyms:BTS 54 505;BTS 54505;BTS-54 505;BTS-54505

Suppliers and Price of Didesmethylsibutramine, (+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Didesmethylsibutramine, (+)-

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:337.9±25.0 °C(Predicted)
PKA:10.82±0.42(Predicted)
Density:1.072±0.06 g/cm3(Predicted)
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:251.1440774
Heavy Atom Count:17
Complexity:239

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N
Isomeric SMILES:CC(C)C[C@H](C1(CCC1)C2=CC=C(C=C2)Cl)N

Technology Process of Didesmethylsibutramine, (+)-

There total 29 articles about Didesmethylsibutramine, (+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₃₂H₃₉ClN₂O₄S₂

: 229639-56-9,84467-54-9
(R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine

: 229639-57-0,84467-54-9
(S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine

Guidance literature:: C₃₂H₃₉ClN₂O₄S₂; With sodium tetrahydroborate; titanium(IV) tetraethanolate; In tetrahydrofuran; at -15 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol;

With sodium hydroxide; In tetrahydrofuran; methanol; Product distribution / selectivity;

Reference yield: 89.5%

: 473554-13-1
(2S,4R,5S)-N-tosyl-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide

: 28049-61-8
1-(4-chlorophenyl)cyclobutanecarbonitrile

: 58107-41-8,58107-43-0,108591-33-9,131142-88-6,143957-01-1,136173-99-4
N-[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]-4-methylbenzenesulfonamide

: 229639-56-9,84467-54-9
(R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine

Guidance literature:: With hydrogenchloride; titanium(IV) tetraethanolate; sodium hydroxide; sodium tetrahydroborate; 2-methylpropylmagnesium chloride; ammonium acetate; water; copper(I) bromide; In tetrahydrofuran; methanol; tert-butyl methyl ether; toluene; at -78 - 20 ℃; for 18 - 20h; Heating / reflux;

Reference yield: 88.0%

: (R)-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3-methyl-butylidene}-sulfinamic acid (1S,2R)-1-phenyl-2-(4-methylphenylsulfonylamino)-propyl ester

: 229639-56-9,84467-54-9
(R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine

: 229639-57-0,84467-54-9
(S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine

Guidance literature:: (R)-{1-[1-(4-chloro-phenyl)-cyclobutyl]-3-methyl-butylidene}-sulfinamic acid (1S,2R)-1-phenyl-2-(4-methylphenylsulfonylamino)-propyl ester; With sodium tetrahydroborate; titanium(IV) isopropylate; In tetrahydrofuran; at -45 - -30 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol;

With sodium hydroxide; In tetrahydrofuran; methanol; Product distribution / selectivity;