R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

Base Information

Chemical Name:R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide
CAS No.:917252-86-9
Molecular Formula:C₁₉H₂₇N₃O₅S
Molecular Weight:409.506
Hs Code.:

Synonyms:R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

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Chemical Property of R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

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Technology Process of R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

There total 4 articles about R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 29968-78-3
2-(4-nitrophenyl)ethylamine monohydrochloride

: 120711-54-8
L-(-)-N-(tert-butyloxycarbonyl)-2,2-dimethylthiazolidinecarboxylic acid pentafluorophenyl ester

: 917252-86-9
R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; for 2h;
DOI:10.1016/j.tet.2006.09.009

Reference yield:

: 5317-15-7
(4R)-3-(tert-butoxycarbonyl)-2,2-dimethylthiazolidine-4-carboxylic acid

: 917252-86-9
R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DCC / ethyl acetate / 3 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 2 h

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2006.09.009

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 917252-86-9
R-2,2-dimethyl-3-(1,1-dimethylethoxycarbonyl)-N-(2-(4-nitrophenyl)ethyl)tetrahydrothiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 11 percent / ethyldiisopropylamine / acetonitrile / 48 h

2: 90 percent / DCC / ethyl acetate / 3 h / 0 °C

3: 93 percent / triethylamine / CH₂Cl₂ / 2 h

With triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2006.09.009