N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid
CAS No.:126632-27-7
Molecular Formula:C₁₉H₂₃FN₆O₆
Molecular Weight:450.427
Hs Code.:

Synonyms:N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

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Chemical Property of N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

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Technology Process of N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

There total 5 articles about N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 126632-36-8
diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-fluorobenzoyl>-L-glutamate

: 126632-27-7
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 55 ℃; for 18h;
DOI:10.1021/jm00086a008

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 126632-27-7
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

2: 98 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 2068.6 Torr

3: 1.) glacial acetic acid, 3A-sieves, 2.) NaBH₃CN / 1.) EtOH, 25 deg C, 2 h 40 min, 2.) EtOH, RT, 23 h

4: 60 percent / 1.0 N aq. NaOH / ethanol / 18 h / 55 °C

With 4-methyl-morpholine; sodium hydroxide; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00086a008

Reference yield:

: 403-21-4
3-fluoro-4-nitrobenzoic acid

: 126632-27-7
N-<4-<<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl>amino>-3-fluorobenzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

2: 98 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 2068.6 Torr

3: 1.) glacial acetic acid, 3A-sieves, 2.) NaBH₃CN / 1.) EtOH, 25 deg C, 2 h 40 min, 2.) EtOH, RT, 23 h

4: 60 percent / 1.0 N aq. NaOH / ethanol / 18 h / 55 °C

With 4-methyl-morpholine; sodium hydroxide; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00086a008