ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate
• CAS No.: 98771-59-6
• Molecular Formula: C₁₇H₂₁N₃O₄
• Molecular Weight: 331.371
• Mol file: 98771-59-6.mol

Synonyms:ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

Chemical Property of ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate

There total 4 articles about ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate (53554-29-3) + 2-(2-methylpropoxy)benzenamine (104065-95-4) → ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (98771-59-6)

Guidance literature:

at 130 ℃; for 2h;

DOI:10.1248/cpb.37.1780

Reference yield:

N-[2-(2-methylpropoxy)phenyl]guanidine + morpholin-4-ylmethylene-malonic acid diethyl ester (62648-61-7) → ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (98771-59-6)

Guidance literature:

With potassium carbonate; In ethanol; chloroform; water;

Reference yield:

1-isobutoxy-2-nitrobenzene (56245-02-4) → ethyl 1,6-dihydro-2-[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidinecarboxylate (98771-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd/C / methanol

2: 74 percent / 2 h / 130 °C

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.37.1780

upstream raw materials:

ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

2-(2-methylpropoxy)benzenamine

1-isobutoxy-2-nitrobenzene

morpholin-4-ylmethylene-malonic acid diethyl ester

Downstream raw materials:

1,6-dihydro-2-<2-(2-methylpropoxy)anilino>-6-oxo-5-pyrimidinecarboxylic acid

ethyl 4-chloro-2-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate

4-methoxy-2-<2-(2-methylpropoxy)anilino>-5-pyrimidineacrboxylic acid

ethyl 4-methoxy-3-<2-(2-methylpropoxy)anilino>-5-pyrimidinecarboxylate hydrochloride