5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine

Base Information

• Chemical Name: 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine
• CAS No.: 1187196-48-0
• Molecular Formula: C₂₄H₁₇Cl₂F₃N₄O
• Molecular Weight: 505.326
• Mol file: 1187196-48-0.mol

Synonyms:5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine

Chemical Property of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine

There total 3 articles about 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(Aminomethyl)pyridine (3731-51-9) + 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile (1187196-47-9) → 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine (1187196-48-0)

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Reflux;

Reference yield:

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzonitrile (930110-37-5) → 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine (1187196-48-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / 1,1-dichloroethane / 3 h / Reflux

2: potassium carbonate / acetonitrile / 3 h / Reflux

With N-Bromosuccinimide; potassium carbonate; 2,2'-azobis(isobutyronitrile); In 1,1-dichloroethane; acetonitrile;

Reference yield:

5-(3,5-dichloro-phenyl)-3-(4-bromo-3-methyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole → 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine (1187196-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / 1,1-dichloroethane / 3 h / Reflux

3: potassium carbonate / acetonitrile / 3 h / Reflux

With N-Bromosuccinimide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In 1,1-dichloroethane; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

2-(Aminomethyl)pyridine

2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile

4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-methyl-benzonitrile

Downstream raw materials:

N-[(1E)-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-ylinden]acetamide