(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

Base Information

Chemical Name:(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol
CAS No.:201472-27-7
Molecular Formula:C₂₅H₃₄O₄Si
Molecular Weight:426.628
Hs Code.:

Synonyms:(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

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Chemical Property of (2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

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Technology Process of (2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

There total 6 articles about (2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 149099-21-8
(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-[2,2']bifuranyl-5-one

: 201472-27-7
(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1021/jo9713621

Reference yield:

: 102717-29-3
(5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one

: 201472-27-7
(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / DIBAL-H / toluene / 1 h / -78 °C

2: 1.) Ac₂O, DMAP, TEA, 2.) BF₃*OEt₂ / 1) CH₂Cl₂, rt, 1 h; 2) CH₂Cl₂, -78 deg C, 1 h

3: 92 percent / H₂ / Pd/C / ethyl acetate / 5 h / 760 Torr

4: 94 percent / DIBAL-H / toluene / 1 h / -78 °C

With dmap; TEA; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; diisobutylaluminium hydride; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jo9713621

Reference yield:

: 201472-26-6
(2R/S,5S)-5-(tert-butyldiphenylsilyloxymethyl)tetrahydrofuran-2-ol

: 201472-27-7
(2R,2'S,5'S)-5'-(tert-Butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Ac₂O, DMAP, TEA, 2.) BF₃*OEt₂ / 1) CH₂Cl₂, rt, 1 h; 2) CH₂Cl₂, -78 deg C, 1 h

2: 92 percent / H₂ / Pd/C / ethyl acetate / 5 h / 760 Torr

3: 94 percent / DIBAL-H / toluene / 1 h / -78 °C

With dmap; TEA; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; diisobutylaluminium hydride; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1021/jo9713621