(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

Base Information

Chemical Name:(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone
CAS No.:1620069-27-3
Molecular Formula:C₁₇H₁₈N₆O₂
Molecular Weight:338.369
Hs Code.:

Synonyms:(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

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Chemical Property of (S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

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Technology Process of (S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

There total 6 articles about (S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₆N₆O₄

: 1620069-27-3
(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

Guidance literature:: With hydrogenchloride; iron; In ethanol; water;
DOI:10.1016/j.bmcl.2014.05.030

Reference yield:

: (1H-imidazol-2-yl)(3-nitrophenyl)methanone

: 1620069-27-3
(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 3 h / 100 °C

2: 3-chloro-benzenecarboperoxoic acid / 2 h / 20 °C

3: 6 h / 60 °C

4: iron; hydrogenchloride / ethanol; water

With hydrogenchloride; iron; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.030

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 1620069-27-3
(S)-(3-aminophenyl)(1-(2-((2-hydroxypropyl)amino)pyrimidin-4-yl)-1H-imidazol-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / pyridine / 0 - 20 °C

1.2: 1 h

2.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / 2 h / 20 °C

4.1: 6 h / 60 °C

5.1: iron; hydrogenchloride / ethanol; water

With hydrogenchloride; iron; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.05.030