t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

Base Information

Chemical Name:t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate
CAS No.:824400-15-9
Molecular Formula:C₂₄H₃₃N₇O₅
Molecular Weight:499.57
Hs Code.:

Synonyms:t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

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Chemical Property of t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

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Technology Process of t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

There total 6 articles about t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 824399-45-3
t-butyl (R)-2-{[3-cyano-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

: 824400-15-9
t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In ethanol; dimethyl sulfoxide; at 60 ℃; for 3h;
DOI:10.1248/cpb.55.881

Reference yield:

: 824397-74-2
2-(3,5-dimethoxyphenylamino)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

: 824400-15-9
t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃; N,N-dimethylaniline / 2 h / 60 °C

2: 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

3: 89 percent / aq. NaOH; H₂O₂ / dimethylsulfoxide; ethanol / 3 h / 60 °C

With sodium hydroxide; dihydrogen peroxide; N,N-dimethyl-aniline; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.55.881

Reference yield:

: 947155-02-4,824397-66-2
5-amino-3-(3,5-dimethoxyphenylamino)pyrazole-1H-4-carbonitrile

: 824400-15-9
t-butyl (R)-2-{[3-carbamoyl-2-(3,5-dimethoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]amino}-1-methylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / AcOH / 10 h / Heating

2: POCl₃; N,N-dimethylaniline / 2 h / 60 °C

3: 1-methyl-pyrrolidin-2-one / 24 h / 20 °C

4: 89 percent / aq. NaOH; H₂O₂ / dimethylsulfoxide; ethanol / 3 h / 60 °C

With sodium hydroxide; dihydrogen peroxide; acetic acid; N,N-dimethyl-aniline; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide;
DOI:10.1248/cpb.55.881