Technology Process of 3-demethoxycarbonyl-3-(4'-tolylamino)methylvinorelbine
There total 4 articles about 3-demethoxycarbonyl-3-(4'-tolylamino)methylvinorelbine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C53H63N5O7;
With
N-Bromosuccinimide; diethylamine; trifluoroacetic acid;
In
dichloromethane;
at -70 ℃;
Inert atmosphere;
Darkness;
With
silver tetrafluoroborate;
In
tetrahydrofuran; dichloromethane; water;
at 50 ℃;
for 3h;
Inert atmosphere;
Darkness;
DOI:10.1016/j.bmcl.2012.10.024
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iron(III) chloride; sodium hydrogen sulfate / water; 2,2,2-trifluoroethanol / 8 h / 25 °C / Inert atmosphere; Darkness
1.2: 0.5 h / 0 °C / Inert atmosphere; Darkness
2.1: N-Bromosuccinimide; trifluoroacetic acid; diethylamine / dichloromethane / -70 °C / Inert atmosphere; Darkness
2.2: 3 h / 50 °C / Inert atmosphere; Darkness
With
iron(III) chloride; sodium hydrogen sulfate; N-Bromosuccinimide; diethylamine; trifluoroacetic acid;
In
dichloromethane; 2,2,2-trifluoroethanol; water;
DOI:10.1016/j.bmcl.2012.10.024
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / 8 h / 20 °C
2.1: iron(III) chloride; sodium hydrogen sulfate / water; 2,2,2-trifluoroethanol / 8 h / 25 °C / Inert atmosphere; Darkness
2.2: 0.5 h / 0 °C / Inert atmosphere; Darkness
3.1: N-Bromosuccinimide; trifluoroacetic acid; diethylamine / dichloromethane / -70 °C / Inert atmosphere; Darkness
3.2: 3 h / 50 °C / Inert atmosphere; Darkness
With
pyridine; iron(III) chloride; sodium hydrogen sulfate; N-Bromosuccinimide; diethylamine; trifluoroacetic acid;
In
dichloromethane; 2,2,2-trifluoroethanol; water;
DOI:10.1016/j.bmcl.2012.10.024
