(R)-Gallopamil

Base Information

Chemical Name:(R)-Gallopamil
CAS No.:38176-10-2
Molecular Formula:C₂₈H₄₀N₂O₅
Molecular Weight:484.636
Hs Code.:
UNII:V8KE5XTM0I
Nikkaji Number:J441.676G
Wikidata:Q27291671
Mol file:38176-10-2.mol

Synonyms:(R)-Gallopamil;(+)-Gallopamil;Gallopamil, (+)-;(+)-Methoxyverapamil;38176-10-2;V8KE5XTM0I;UNII-V8KE5XTM0I;D-D-600;(+)-D 600;(2R)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile;alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)benzeneacetonitrile, (R)-;Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-, (alphaR)-;GALLOPAMIL, (R)-;Q27291671;.ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4,5-TRIMETHOXY-.ALPHA.-(1-METHYLETHYL)BENZENEACETONITRILE, (R)-;BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4,5-TRIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, (.ALPHA.R)-

Suppliers and Price of (R)-Gallopamil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
R-(+)-VERAPAMIL HYDROCHLORIDE 95.00%
5MG
$ 495.83

American Custom Chemicals Corporation
R-(+)-VERAPAMIL HYDROCHLORIDE 95.00%
1MG
$ 367.50

Total 5 raw suppliers

Chemical Property of (R)-Gallopamil

Chemical Property:

PSA：63.95000
LogP:5.89508
Solubility.:H2O: >30 mg/mL
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:14
Exact Mass:484.29372238
Heavy Atom Count:35
Complexity:639

Purity/Quality:

98%min ^*data from raw suppliers

R-(+)-VERAPAMIL HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC
Isomeric SMILES:CC(C)[C@@](CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC

Technology Process of (R)-Gallopamil

There total 10 articles about (R)-Gallopamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13230-71-2
N-[2-(3,4-dimethoxyphenyl)ethyl]-2,2,2-trifluoroacetamide

: 38176-10-2
(+)-Gallopamil

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature

2: tetrahydrofuran / 48 h / 80 °C

With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00383a026

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 38176-10-2
(+)-Gallopamil

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / CH₂Cl₂ / 1 h / 0 °C

2: 82 percent / NaH / tetrahydrofuran / 4 h / Ambient temperature

3: tetrahydrofuran / 48 h / 80 °C

With sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00383a026

Reference yield:

: 107148-95-8,107148-96-9,107148-97-0,107148-98-1
(2S,3R)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

: 38176-10-2
(+)-Gallopamil

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) THF, 45 deg C, 4 h, 2.) THF, from 0 deg C to RT, 14 h

2: 94 percent / NH₃, AlMe₃ / 1,1,2-trichloro-ethane; toluene / 60 h / Heating

3: 96 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

4: 92 percent / NaBH₄, tert-butyl alcohol / CH₂Cl₂ / 70 h / Heating

5: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 1 h, 2.) THF, H₂O, 0 deg C, 30 min

6: Et₃N / CH₂Cl₂ / 24 h / 0 °C

7: tetrahydrofuran / 48 h / 80 °C

With sodium tetrahydroborate; 2-methyl-but-2-ene; borane; ammonia; dihydrogen peroxide; trimethylaluminum; sodium hydride; triethylamine; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; 1,1,2-trichloroethane; toluene;
DOI:10.1021/jo00383a026