2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester
• CAS No.: 423771-75-9
• Molecular Formula: C₅₇H₉₂O₇Si₂
• Molecular Weight: 945.524

Synonyms:2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester

Chemical Property of 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid (3R,4R,5R,6R,9S,13S,15R)-10-acetoxy-11-benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadecyl ester → 2,2-Dimethyl-propionic acid (Z)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester + 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester (423771-75-9)

Guidance literature:

With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 1.66667h;

DOI:10.1016/S0040-4020(01)01206-6

Reference yield:

2,2-Dimethyl-propionic acid (3R,4R,5R,6R,9S)-5-(tert-butyl-dimethyl-silanyloxy)-9-methoxy-4,6-dimethyl-10-oxo-3-triethylsilanyloxy-decyl ester (179945-05-2) → 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester (423771-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: BuLi / tetrahydrofuran; hexane / 135 h / -78 °C

2: DMAP; pyridine / 2 h / 20 °C

3: 73.4 mg / 5 percent Na-Hg; Na₂HPO₄ / methanol / 1.67 h / 0 °C

With pyridine; dmap; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; In tetrahydrofuran; methanol; hexane;

DOI:10.1016/S0040-4020(01)01206-6

Reference yield:

C33H36O4S (157430-93-8) → 2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-triethylsilanyloxy-16-trityloxy-hexadec-10-enyl ester (423771-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: BuLi / tetrahydrofuran; hexane / 135 h / -78 °C

2: DMAP; pyridine / 2 h / 20 °C

3: 73.4 mg / 5 percent Na-Hg; Na₂HPO₄ / methanol / 1.67 h / 0 °C

With pyridine; dmap; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; In tetrahydrofuran; methanol; hexane;

DOI:10.1016/S0040-4020(01)01206-6

upstream raw materials:

2,2-Dimethyl-propionic acid (3R,4R,5R,6R,9S)-5-(tert-butyl-dimethyl-silanyloxy)-9-methoxy-4,6-dimethyl-10-oxo-3-triethylsilanyloxy-decyl ester

C₃₃H₃₆O₄S

Downstream raw materials:

2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-9,15-dimethoxy-4,6,13-trimethyl-16-trityloxy-hexadec-10-enyl ester

(2E,4E,14E,20E)-(7R,8R,9R,10R,13S,17R,19R,23S,24R,25S,26S)-9-(tert-Butyl-dimethyl-silanyloxy)-23,25-dihydroxy-13,19-dimethoxy-8,10,17,24,26-pentamethyl-7-methylsulfanylmethoxy-27-trityloxy-heptacosa-2,4,14,20-tetraenoic acid ethyl ester

C₇₁H₁₁₁NO₁₀Si₂

2,2-Dimethyl-propionic acid (E)-(3R,4R,5R,6R,9S,13R,15R)-5-(tert-butyl-dimethyl-silanyloxy)-9,15-dimethoxy-4,6,13-trimethyl-3-methylsulfanylmethoxy-16-trityloxy-hexadec-10-enyl ester

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