6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Base Information

Chemical Name:6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine
CAS No.:1198109-53-3
Molecular Formula:C₁₂H₁₂ClFN₄O
Molecular Weight:282.705
Hs Code.:

Synonyms:6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

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Chemical Property of 6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

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Technology Process of 6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

There total 1 articles about 6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 458-52-6
2-fluoro-4-(methoxy)aniline

: 1198109-53-3
6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

Guidance literature:: 5-amino-4,6-dichloro-2-methylpyrimidine; 2-fluoro-4-(methoxy)aniline; With hydrogenchloride; In ethanol; water; at 80 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1445-45-0
Trimethyl orthoacetate

: 1198109-53-3
6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

: 1198109-54-4
6-chloro-9-(2-fluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purine

Guidance literature:: Trimethyl orthoacetate; 6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine; With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 1198109-53-3
6-chloro-4-N-(2-fluoro-4-methoxyphenyl)-2-methylpyrimidine-4,5-diamine

: 1198108-93-8
dicyclopropylmethyl-[9-(2-fluoro-4-methoxyphenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 16 h / 110 °C / Inert atmosphere

2: triethylamine / butan-1-ol / 12 h / Reflux; Inert atmosphere

With toluene-4-sulfonic acid; triethylamine; In toluene; butan-1-ol;