N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

Base Information

Chemical Name:N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide
CAS No.:1318131-14-4
Molecular Formula:C₂₈H₂₇BrCl₂N₆O₄S
Molecular Weight:694.436
Hs Code.:

Synonyms:N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

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Chemical Property of N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

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Technology Process of N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

There total 13 articles about N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1318133-22-0
4-(4-ethylpiperazin-1-yl)benzamide

: 1318130-12-9
N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-chlorothieno[3,2-d]pyrimidine-7-carboxamide

: 1318131-14-4
N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 120 ℃; for 2.5h;

Reference yield:

: 209286-57-7
7-(bromomethyl)-4-chlorothieno[3,2-d]pyrimidine

: 1318131-14-4
N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium iodide / N,N-dimethyl-formamide / 4 h / 35 °C

2.1: sodium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

3.1: manganese(IV) oxide / chloroform / 2 h / 70 °C

4.1: sodium chlorite; sodium dihydrogenphosphate dihydrate / water; dimethyl sulfoxide / 0 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

6.1: sulfuryl dichloride / dichloromethane; acetonitrile / 1 h / 0 - 20 °C

6.2: pH 8

7.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

With manganese(IV) oxide; sodium chlorite; sulfuryl dichloride; sodium dihydrogenphosphate dihydrate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 1318131-14-4
N-(4-bromo-2,6-dichloro-3,5-dimethoxyphenyl)-4-(4-(4-ethylpiperazin-1-yl)benzamido)thieno[3,2-d]pyrimidine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra-N-butylammonium tribromide / dichloromethane / -78 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 15 h / 20 °C

3.1: sulfuryl dichloride / dichloromethane; acetonitrile / 1 h / 0 - 20 °C

3.2: pH 8

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2.5 h / 120 °C

With sulfuryl dichloride; tetra-N-butylammonium tribromide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; acetonitrile;