2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

Base Information

Chemical Name:2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide
CAS No.:875271-89-9
Molecular Formula:C₄₆H₃₄N₂O₃S
Molecular Weight:694.854
Hs Code.:

2-[2-phenyl-5-(2-phenyl-1<i>H</i>-indole-6-carbonyl)-thiophen-3-yl]-<i>N</i>-trityloxy-acetamide

Synonyms:2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

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Chemical Property of 2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

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Technology Process of 2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

There total 10 articles about 2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 875271-72-0
[2-Phenyl-5-(2-phenyl-1H-indole-6-carbonyl)thiophene-3-yl]acetic acid

: 31938-11-1
O-tritylhydroxylamine

: 875271-89-9
2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-79-7
(2-phenylthiophen-3-yl)acetic acid methyl ester

: 875271-89-9
2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

2: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

3: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

4: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

5: 87 percent / NaOH / methanol; tetrahydrofuran / 4 h / 20 °C

6: 100 percent / HATU; N-hydroxybenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hydroxide; copper(l) iodide; aluminium trichloride; benzotriazol-1-ol; diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018

Reference yield:

: 875271-86-6
(2-phenylthiophen-3-yl)acetic acid ethyl ester

: 875271-89-9
2-[2-phenyl-5-(2-phenyl-1H-indole-6-carbonyl)-thiophen-3-yl]-N-trityloxy-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: KOH / methanol / 3 h / Heating

2: 3.3 g / HCl / 5 h / Heating

3: 74 percent / AlCl₃ / CH₂Cl₂ / 20 °C

4: 96 percent / stannous chloride dihydrate / ethyl acetate / 0.5 h / Heating

5: 98 percent / Et₂NH; CuI / Pd(PPh₃)4 / 4 h / 20 °C

6: 61 percent / PdCl₂(PhCN)2 / dimethylformamide / 0.5 h / 80 °C

7: 87 percent / NaOH / methanol; tetrahydrofuran / 4 h / 20 °C

8: 100 percent / HATU; N-hydroxybenzotriazole; ethyldiisopropylamine / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; copper(l) iodide; aluminium trichloride; benzotriazol-1-ol; diethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2005.08.018