5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

Base Information

Chemical Name:5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate
CAS No.:1350911-45-3
Molecular Formula:C₁₉H₂₅NO₂
Molecular Weight:299.413
Hs Code.:

Synonyms:5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

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Chemical Property of 5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

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Technology Process of 5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

There total 5 articles about 5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 917-92-0
3,3-Dimethylbut-1-yne

: 1350911-20-4
1-iodovinyl isopropyl-p-tolylcarbamate

: 1350911-45-3
5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/ol2029355

Reference yield:

: 1350911-14-6
vinyl isopropyl-p-tolylcarbamate

: 1350911-45-3
5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 15 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; triethylamine; In tetrahydrofuran; 2.1: Sonogashira coupling;
DOI:10.1021/ol2029355

Reference yield:

: 1350911-09-9
N-isopropyl-N-p-tolylcarbamoylchloride

: 1350911-45-3
5,5-dimethylhex-1-en-3-yn-2-yl isopropyl-p-tolylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 4 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 15 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; triethylamine; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 3.1: Sonogashira coupling;
DOI:10.1021/ol2029355