4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

Base Information

Chemical Name:4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone
CAS No.:1617498-96-0
Molecular Formula:C₂₂H₂₆N₆O₂
Molecular Weight:406.487
Hs Code.:

Synonyms:4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

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Chemical Property of 4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

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Technology Process of 4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

There total 3 articles about 4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

: 110-91-8,99108-56-2
morpholine

: 1617499-21-4
4-(6-amino-5-(1-isopropyl-1H-1,2,3-triazol-4-yl)pyridin-3-yl)-2-methylbenzoic acid

: 1617498-96-0
4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1617499-16-7
5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine

: 1617498-96-0
4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

1.2: 3 h / 100 °C

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1210838-82-6
5-bromo-3-ethynyl-pyridin-2-ylamine

: 1617498-96-0
4-[ 6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-2-methylphenylmorpholinomethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

2.2: 3 h / 100 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol;