N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

Base Information

Chemical Name:N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide
CAS No.:1592907-77-1
Molecular Formula:C₃₂H₄₁ClN₂O₇
Molecular Weight:601.14
Hs Code.:

N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

Synonyms:N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

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Chemical Property of N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

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Technology Process of N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

There total 4 articles about N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1592907-60-2
N-allyl-4-chloro-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy )-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)benzamide

: 106-95-6
allyl bromide

: 1592907-77-1
N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

Guidance literature:: N-allyl-4-chloro-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy )-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)benzamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; at 0 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1592907-30-6
C₁₆H₂₀ClNO₃

: 1592907-77-1
N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.2: 6 h / 0 °C / Inert atmosphere

With lithium borohydride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1592907-45-3
(2S,3S)-ethyl 3-((S)-2-(N-allyl-4-chlorobenzamido)-4-methylpentanamido)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-carboxylate

: 1592907-77-1
N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-4-methyl-1-oxopentan-2-yl)-4-chlorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 °C / Inert atmosphere

With lithium borohydride; sodium hydride; In tetrahydrofuran;
DOI:10.1002/ejoc.201301769