4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

Base Information

Chemical Name:4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid
CAS No.:1394825-02-5
Molecular Formula:C₂₅H₂₂N₄O₇
Molecular Weight:490.472
Hs Code.:

Synonyms:4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

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Chemical Property of 4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

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Technology Process of 4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

There total 3 articles about 4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1271724-99-2
4-[4-(4-bromo-phenyl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

: 182163-96-8
3,4,5-trimethoxyphenylboronic Acid

: 1394825-02-5
4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In tetrahydrofuran; water; at 120 ℃; under 12929 Torr; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.05.014

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1394825-02-5
4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; copper; copper(II) sulfate / water; tert-butyl alcohol / 0.5 h / 120 °C / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; copper; copper(II) sulfate; cesium fluoride; In tetrahydrofuran; water; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2012.05.014

Reference yield:

: 55715-03-2
4-bromomethyl-3-nitrobenzoic acid

: 1394825-02-5
4-[4-(3',4',5'-trimethoxy-biphenyl-4-yl)-[1,2,3]triazol-1-ylmethyl]-3-nitro-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; copper; copper(II) sulfate / water; tert-butyl alcohol / 0.5 h / 120 °C / Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; copper; copper(II) sulfate; cesium fluoride; In tetrahydrofuran; water; tert-butyl alcohol; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2012.05.014