(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

Base Information

Chemical Name:(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate
CAS No.:1048965-97-4
Molecular Formula:C₂₂H₂₂ClFN₄O₆S
Molecular Weight:524.957
Hs Code.:

Synonyms:(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

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Chemical Property of (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

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Technology Process of (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

There total 10 articles about (E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1257424-14-8
C₁₂H₁₄ClFN₄O₇S₃

: 117428-49-6
methyl (E)-2-(2-bromomethylphenyl)-3-methoxyacrylate

: 1048965-97-4
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3390/molecules15129024

Reference yield:

: 112006-20-9
C₉H₈ClFN₂O₂

: 1048965-97-4
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / Reflux

2: sulfuric acid; nitric acid / 0 - 20 °C

3: iron; ammonium chloride / ethanol; water / Reflux

4: triethylamine / dichloromethane / 0 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With sulfuric acid; diphenyl phosphoryl azide; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Schmidt reaction;
DOI:10.3390/molecules15129024

Reference yield:

: 139191-69-8
methyl 3-hydroxy-2-(2'-methyl)phenyl-2-propenoate

: 1048965-97-4
(E)-methyl 2-(2-((1-(4-chloro-2-fluoro-5-(methylsulfonamido)phenyl)-3-methyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)methyl)phenyl)-3-methoxyacrylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile)

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.3390/molecules15129024