N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

Base Information

Chemical Name:N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide
CAS No.:1310493-39-0
Molecular Formula:C₁₀H₁₉F₃N₂O₂S
Molecular Weight:288.334
Hs Code.:

Synonyms:N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

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Chemical Property of N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

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Technology Process of N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

There total 5 articles about N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 825-63-8,53369-73-6,53369-74-7
(1S,2S)-2-[(dimethylamino)methyl]cyclohexanamine

: 1310493-39-0
N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

Guidance literature:: With triethylamine; In chloroform; at -40 - 20 ℃; for 3h;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-66-3
N-[(1S,2R)-2-(dimethylcarbamoyl)cyclohexyl]benzamide

: 1310493-39-0
N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 96 h / 0 °C / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 70 °C / 760.05 Torr

3: triethylamine / chloroform / 3 h / -40 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jo200834n

Reference yield:

: 1310493-67-4
N-benzyl-(1S,2S)-2-[(dimethylamino)methyl]cyclohexanamine

: 1310493-39-0
N-{(1S,2S)-2-[(dimethylamino)methyl]cyclohexyl}trifluoromethanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 70 °C / 760.05 Torr

2: triethylamine / chloroform / 3 h / -40 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In ethanol; chloroform;
DOI:10.1021/jo200834n