3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

Base Information

Chemical Name:3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol
CAS No.:1394204-58-0
Molecular Formula:C₂₁H₂₃F₂NO
Molecular Weight:343.417
Hs Code.:

Synonyms:3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

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Chemical Property of 3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

Chemical Property:

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Technology Process of 3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

There total 2 articles about 3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394148-02-7
3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-one hydrochloride

: 1394204-58-0
3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2012.04.030

Reference yield:

: 37581-40-1
4-benzyl-1,2,3,6-tetrahydropyridine hydrochloride

: 1394204-58-0
3-(4-benzyl-5,6-dihydropyridin-1(2H)-yl)-1-(2,4-difluorophenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 5 h / Reflux

1.2: 1 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In methanol; ethanol; water; 1.1: Mannich reaction;
DOI:10.1016/j.ejmech.2012.04.030