(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester
CAS No.:852065-20-4
Molecular Formula:C₂₄H₃₉N₃O₄
Molecular Weight:433.591
Hs Code.:

Synonyms:(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

There total 4 articles about (S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852065-19-1
N,N-diisopropyl-2-isopropylamino-terephthalamic acid

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 852065-20-4
(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1021/ja0446404

Reference yield:

: 852065-17-9
2-amino-N,N-diisopropyl-terephthalamic acid methyl ester

: 852065-20-4
(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Zn; AcOH

2: aq. NaOH / methanol

3: 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl

With sodium hydroxide; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In methanol;
DOI:10.1021/ja0446404

Reference yield:

: 35092-89-8
4-(methoxycarbonyl)-3-nitrobenzoic acid

: 852065-20-4
(S)-2-(4-Diisopropylcarbamoyl-2-isopropylamino-benzoylamino)-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride; DMF / CH₂Cl₂

2: CH₂Cl₂

3: SnCl₂ / ethyl acetate / 0 °C

4: Zn; AcOH

5: aq. NaOH / methanol

6: 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl

With sodium hydroxide; oxalyl dichloride; acetic acid; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; tin(ll) chloride; zinc; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/ja0446404