3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

Base Information

Chemical Name:3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester
CAS No.:1006379-94-7
Molecular Formula:C₂₉H₃₀Cl₂F₂N₂O₄
Molecular Weight:579.471
Hs Code.:

Synonyms:3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

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Chemical Property of 3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

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Technology Process of 3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

There total 1 articles about 3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1006379-93-6
N-[2-(2,6-dichlorophenyl)-4-(2,4-difluorobenzoyl)pyridin-3-yl]-2,2-dimethylpropanamide

: 540-88-5
acetic acid tert-butyl ester

: 1006379-94-7
3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

Reference yield: 90.0%

: 1006379-94-7
3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester

: 1006379-95-8
8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-1,7-naphthyridin-2(1H)-one

Guidance literature:: 3-[2-(2,6-dichlorophenyl)-3-(2,2-dimethylpropionylamino)-pyridin-4-yl]-3-(2,4-difluorophenyl)-3-hydroxypropionic acid tert-butyl ester; With hydrogenchloride; at 100 ℃;

With water; potassium carbonate;