ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate

Base Information

• Chemical Name: ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate
• CAS No.: 1333162-63-2
• Molecular Formula: C₂₀H₂₅NO₅
• Molecular Weight: 359.422
• Mol file: 1333162-63-2.mol

Synonyms:ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate

Chemical Property of ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate

There total 2 articles about ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 2-benzoyl-4,5-dimethoxyphenethylcarbamate (1333162-51-8) → ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate (1333162-63-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 0.5h;

DOI:10.3390/molecules16087019

Reference yield:

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester (17889-63-3) → ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate (1333162-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / dichloromethane / 3 h / 80 °C

2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; In dichloromethane; 1: Friedel Crafts acylation;

DOI:10.3390/molecules16087019

Reference yield: 88.0%

ethyl 2-(hydroxy(phenyl)methyl)-4,5-dimethoxyphenethylcarbamate (1333162-63-2) → (±)-ethyl 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (73083-01-9)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.3390/molecules16087019

upstream raw materials:

ethyl 2-benzoyl-4,5-dimethoxyphenethylcarbamate

N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester

Downstream raw materials:

(±)-ethyl 6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate