3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

Base Information

Chemical Name:3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester
CAS No.:850795-94-7
Molecular Formula:C₅₈H₇₆O₁₂Si₂
Molecular Weight:1021.41
Hs Code.:

3,5-bis-benzyloxy-2-{3-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

Synonyms:3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

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Chemical Property of 3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

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Technology Process of 3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

There total 12 articles about 3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 850795-94-7
3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 0.166667h;
DOI:10.1021/ja045520z

Reference yield:

: 850795-82-3
[4-(2,4,6-tris(methoxymethoxy)phenyl)but-3-enyloxy]-tert-butyldimethylsilyl ether

: 850795-94-7
3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: Ag₂O; aq. I₂ / dioxane / 3 h / 0 - 20 °C

2.1: 8.4 g / DIPEA / tetrahydrofuran / 0 - 20 °C

3.1: 93 percent / NBS / CHCl₃ / 1 h

4.1: n-BuLi / pentane; hexane / 0.03 h / -45 °C

4.2: 83 percent / hexane; pentane / 1 h / -45 °C

5.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.67 h

6.1: 3.8 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.5 h

7.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -100 - -78 °C

8.1: tetrapropylammonium perruthenate; N-methylmorpholine-N-oxide; molecular sieves 4A / CH₂Cl₂ / 0.5 h / 0 - 25 °C

9.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / pyridine; 2-methyl-propan-2-ol / 0 - 25 °C

10.1: 2.2 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.17 h / 25 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; iodine; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; pyridine; hexane; dichloromethane; chloroform; tert-butyl alcohol; pentane; 5.1: Pinnick oxidation / 6.1: Mitsunobu reaction / 9.1: Pinnick oxidation / 10.1: Mitsunobu reaction;
DOI:10.1021/ja045520z

Reference yield:

: 850795-83-4
4-(tert-butyl-dimethyl-silanyloxy)-2-(2,4,6-tris-methoxymethoxy-phenyl)-butyraldehyde

: 850795-94-7
3,5-bis-benzyloxy-2-{3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carbonyl}-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: 8.4 g / DIPEA / tetrahydrofuran / 0 - 20 °C

2.1: 93 percent / NBS / CHCl₃ / 1 h

3.1: n-BuLi / pentane; hexane / 0.03 h / -45 °C

3.2: 83 percent / hexane; pentane / 1 h / -45 °C

4.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.67 h

5.1: 3.8 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.5 h

6.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -100 - -78 °C

7.1: tetrapropylammonium perruthenate; N-methylmorpholine-N-oxide; molecular sieves 4A / CH₂Cl₂ / 0.5 h / 0 - 25 °C

8.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / pyridine; 2-methyl-propan-2-ol / 0 - 25 °C

9.1: 2.2 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.17 h / 25 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4 A molecular sieve; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; hexane; dichloromethane; chloroform; tert-butyl alcohol; pentane; 4.1: Pinnick oxidation / 5.1: Mitsunobu reaction / 8.1: Pinnick oxidation / 9.1: Mitsunobu reaction;
DOI:10.1021/ja045520z