(6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

Base Information

Chemical Name:(6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one
CAS No.:799795-64-5
Molecular Formula:C₂₀H₁₅N₃O₂
Molecular Weight:329.358
Hs Code.:
DSSTox Substance ID:DTXSID601333359
Nikkaji Number:J3.024.764G
ChEMBL ID:CHEMBL1487936

Synonyms:MLS001164892;CHEMBL1487936;SMR000540152;BDBM67668;cid_6097961;REGID_for_CID_6097961;DTXSID601333359;HMS2880P22;STK549087;AKOS005476788;(6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one;NCGC00275994-01;799795-64-5;2-[4-(4-hydroxyanilino)quinazolin-2-yl]phenol;AB00824459-06;2-{4-[(4-hydroxyphenyl)amino]quinazolin-2-yl}phenol;BRD-K62712624-001-07-1;(6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone;(6E)-6-[4-[(4-hydroxyphenyl)amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

Suppliers and Price of (6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:329.116426730
Heavy Atom Count:25
Complexity:427

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=NC(=N2)C3=CC=CC=C3O)NC4=CC=C(C=C4)O

Technology Process of (6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one

There total 5 articles about (6E)-6-[4-(4-hydroxyanilino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₂₂H₁₉N₃O₂

: 799795-64-5
2-(4-((4-hydroxyphenyl)amino)quinazolin-2-yl)phenol

Guidance literature:: With hydrogen bromide; acetic acid; for 10h; Reflux;
DOI:10.1016/j.ejmech.2016.06.040

Reference yield:

: 108240-11-5
4-chloro-2-(2-methoxyphenyl)quinazoline

: 799795-64-5
2-(4-((4-hydroxyphenyl)amino)quinazolin-2-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

2: hydrogen bromide; acetic acid / 10 h / Reflux

With hydrogen bromide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.06.040

Reference yield:

: 1028-96-2
2-(2-methoxyphenyl)quinazolin-4(3H)-one

: 799795-64-5
2-(4-((4-hydroxyphenyl)amino)quinazolin-2-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 5 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

3: hydrogen bromide; acetic acid / 10 h / Reflux

With thionyl chloride; hydrogen bromide; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.06.040