(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Base Information

Chemical Name:(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol
CAS No.:1253197-73-7
Molecular Formula:C₂₁H₂₇NO₂
Molecular Weight:325.451
Hs Code.:

Synonyms:(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

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Chemical Property of (1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

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Technology Process of (1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

There total 3 articles about (1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1253197-82-8
(1S,2S)-7-benzyloxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

: 1253197-73-7
(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; under 750.075 Torr; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00897

Reference yield:

: 1253197-69-1
(1S,2S)-7-benzyloxy-2-methyl-3-(p-tosyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

: 1253197-73-7
(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; magnesium / 36 h / Inert atmosphere; Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 72 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 750.08 Torr / Inert atmosphere

With methanol; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00897

Reference yield:

: 1253197-80-6
(1S,2S)-7-benzyloxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol

: 1253197-73-7
(1S,2S)-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 72 h / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 750.08 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; In methanol; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00897