cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol

Base Information

• Chemical Name: cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol
• CAS No.: 1025940-63-9
• Molecular Formula: C₂₀H₂₂N₂O₂S
• Molecular Weight: 354.473
• Mol file: 1025940-63-9.mol

Synonyms:cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol

Chemical Property of cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol

There total 3 articles about cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol (1025940-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 12 h / 20 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition;

DOI:10.1021/jm9904102

Reference yield:

2-(chloromethyl)[1,3]thiazolo[5,4-b]pyridine (110704-35-3) → cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol (1025940-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 12 h / 20 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition;

DOI:10.1021/jm9904102

Reference yield:

cyclohexylmagnesiumchloride (931-51-1) + 4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-benzaldehyde → cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methanol (1025940-63-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jm9904102

upstream raw materials:

cyclohexylmagnesiumchloride

4-hydroxy-benzaldehyde

2-(chloromethyl)[1,3]thiazolo[5,4-b]pyridine

Downstream raw materials:

2-{cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methoxy}-isoindole-1,3-dione

O-{cyclohexyl-[4-(thiazolo[5,4-b]pyridin-2-ylmethoxy)-phenyl]-methyl}-hydroxylamine